Publications

Complete List of Published Work in MyBibliography:

http://www.ncbi.nlm.nih.gov/sites/myncbi/1Da4eoNHhzfQv/bibliography/48804735/public/?sort=date&direction=ascending.

Peer reviewed publications in print or other media

  1. Deng Z, A Lee, T Lin, S Taneja, D Kowdley, JH Leung, M Hill, J Fitzgerald, L Yu, JJ Blakeslee, KL
    Townsend, Z Weil, JR Parquette, O Ziouzenkova. Differential seizure-related mortality and synaptic
    regulation in insulin and amino acid compound 2 (AAC2)-treated APP/PS1 mice mimicking
    Alzheimer’s disease (2024), under revised resubmission.
  2. Roy D, Dion E, Sepeda JA, Peng J, Lingam SR, Townsend K, Sas A, Sun W, and Tedeschi A (2024) α2δ1-mediated Maladaptive Sensory Plasticity Disrupts Adipose Tissue Homeostasis
    Following Spinal Cord Injury. Cell Reports Medicine (IF14.3) (in press, Mar 2024)
  3. Blaszkiewicz M, T Tao, K Mensah-Arhin, R Bates, W Huang, L Cao, R Smith, KL Townsend*. Gene
    therapy approaches for obesity-induced adipose neuropathy, including device-targeted neurotrophic
    factor delivery to subcutaneous adipose. Molecular Therapy (IF 12.4), 2024, Accepted and In Press,
    Image selected for Cover.
  4. Willows JW, M Robinson, Z Alshahal, SK Morrison, G Mishra, H Cyr, M Blaszkiewicz, G Gunsch, S
    DiPietro, E Paradie, B Tero, A Harrington, L Ryzhova, L Liaw, PC Reifsnyder, DE Harrison, KL
    Townsend*. Age-related changes to adipose tissue and peripheral neuropathy in genetically diverse
    HET3 mice differ by sex and are not mitigated by rapamycin longevity treatment. Aging Cell 22(4)
    e13784; 16 Feb 2023; this article received the Featured Cover of the April 2023 issue of Aging Cell
    https://onlinelibrary.wiley.com/doi/10.1111/acel.13843
  5. Willows JW, Z Alshahal, NM Story, M Alvez, P Vidal, H Harris, R Rodrigo, KI Stanford, J Peng, PC
    Reifsnyder, DE Harrison, WD Arnold, KL Townsend*. Contributions of mouse genetic strain
    background to age-related phenotypes in non-sedentary HET3 mice. Neurobiology of Aging, 2024,
    Accepted and In Press.
  6. Blaszkiewicz M, L Caron, B Villinski, J Passarelli, J Donnelly, JM Towne, NM Story, E Merchant, F Khan, N Emanetoglu, L Kass, RL Smith, KL Townsend*. Transdermal electrophysiological recordings of diabetic peripheral neuropathy using a needle electrode array in mice and men. Under Revised Resubmission, 2023. Posted on BioRxiv 2023: https://www.biorxiv.org/content/10.1101/2023.03.03.530993v1
  7. Blaszkiewicz M, G Gunsch, J Willows, M Gardner, JA Sepeda, A Sas, KL Townsend*. Adipose
    tissue myeloid-lineage neuroimmune cells express genes important for neural plasticity and regulate
    adipose innervation. (2022) Frontiers in Endocrinology 13:864925.
    https://www.frontiersin.org/articles/10.3389/fendo.2022.864925/full
  8. Townsend KL*, E Pritchard, JM Coburn, YM Kwon, M Blaszkiewicz, MD Lynes, DL Kaplan, YH
    Tseng*. Silk hydrogel-mediated delivery of bone morphogenetic protein 7 directly to subcutaneous
    white adipose tissue increases browning and energy expenditure. (2022) Front Bioeng Biotechnol.
    10:884601. * co-corresponding authors.
    https://www.frontiersin.org/articles/10.3389/fbioe.2022.884601/full
  9. Willows JW, M Blaszkiewicz and KL Townsend*. STAR Protocols: A clearing-free protocol for
    imaging intact whole adipose tissue innervation in mice. Cell Press, STAR Protocols. 2022, Vol
    3(1), 101109. https://www.sciencedirect.com/science/article/pii/S2666166721008157
  10. Jensen G, JW Willows, DT Breault, KL Townsend*. Lineage tracing of inducible fluorescently-labeled stem cells in the adult mouse brain. (2022) JOVE, April 2022.
    https://www.jove.com/v/63998/lineage-tracing-inducible-fluorescently-labeled-stem-cells-adult
  11. Willows JW, G Gunsch, E Paradie, M Blaszkiewicz, KL Townsend*. Schwann cells contribute to
    demyelinating diabetic neuropathy and nerve terminal structures in white adipose tissue. (2023)
    iScience 26(3):106189. (also on BioRxiv Sept 8, 2022) https://pubmed.ncbi.nlm.nih.gov/36895649
  12. Jensen C^, Beaulieu, A^, C Curtis, J Passarelli, M Blaszkiewicz, S Thomas, T Morin, JW Willows,
    CW Greco, CJ Brennan, C Aniapam, L Caron, MJ Alves, MD Lynes, DL Carlone, DT Breault, KL
    Townsend*. Telomerase reverse transcriptase (TERT)-expressing cells mark a novel stem cell
    population in the adult mouse brain. Under Revised Resubmission, 2023; ^equal contributing first
    authors; Posted on BioRxiv 2023: https://biorxiv.org/cgi/content/short/2023.02.09.527879v1
  13. Blaszkiewicz M, CP Johnson, JW Willows, ML Gardner, DR Taplin, Z Alshahal, MA Freitas, A Khalil,
    MD Lynes, KL Townsend*. Cold-induced early transition to browning in the mouse subcutaneous
    white adipose tissue involves proteins related to nerve remodeling, cytoskeleton, mitochondria, and
    immune cells. Under revised re-submission, 2023.
  14. Lynes MD, DL Carlone, KL Townsend, DT Breault, Y-H Tseng. Telomerase reverse transcriptase
    expression marks a population of rare adipose tissue stem cells. Stem Cells (2022), 40(1), 102-111.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9199842/
  15. Harling M, J Juybari, CP Johnson, KL Townsend, A Khalil, K Tilbury. Wavelet-based
    characterization of the spatial relationship of nerve and collagen in neuropathic adipose tissue. SPIE
    digital library, Feb 20, 2020, Proceedings Volume 11245, Three-Dimensional and Multidimensional
    Microscopy: Image Acquisition and Processing XXVII; 112450R (2020).
    https://doi.org/10.1117/12.2546918
  16. Blaszkiewicz M., Wood E., Koizar S., Willows J., Anderson R., Tseng Y-H., Godwin J., Townsend
    K.L.* The Involvement of Neuroimmune Cells in Adipose Innervation Molecular Medicine 26,
    Article number: 126 (2020). https://molmed.biomedcentral.com/articles/10.1186/s10020-020-00254-3
  17. Willows J.W., Blaszkiewicz M., Lamore A., Borer S., Dubois A., Garner E., Breeding P., Tilbury K.,
    Khalil A., Townsend K.L.* Visualization and analysis of whole depot adipose tissue innervation.
    (2021) iScience Volume 24, Issue 10, 22 October 2021, 103127.
    https://pubmed.ncbi.nlm.nih.gov/34622172/
  18. Blaszkiewicz M, Willows JW, Dubois AL, Waible S, DiBello K, Lyons LL, Johnson C., Paradie E.,
    Banks N., Motyl K., Merilla M., Harrison B., Townsend K.L.* (2019) Neuropathy and neural plasticity
    in the subcutaneous white adipose depot. PLoS ONE 14(9): e0221766.
    https://doi.org/10.1371/journal.pone.0221766
  19. Breeding PW, M Blaszkiewicz, K Townsend, A Khalil, KB Tilbury. Exploratory Investigations of the spatial relationships of collagen and nerves in subcutaneous white adipose tissue (scWAT) using 2-photon microscopy. SPIE Digital Library, Proceedings Volume 10882, Multiphoton Microscopy in the Biomedical Sciences XIX; 1088218 (2019) https://doi.org/10.1117/12.2510753
  20. Miller J#, M Blaszkiewicz#, C. Beaton, CP Johnson, S Waible, A Dubois, A Klemmer, M Kiebish, KL Townsend*. A peroxidized omega-3-enriched polyunsaturated diet leads to adipose and metabolic dysfunction. (2019) J Nutr Biochem. (64): 50-60. # Equal contributing first authors. https://pubmed.ncbi.nlm.nih.gov/30439568/
  21. Townsend KL*, Madden C, Blaszkiewicz M, McDougall LM, Tupone D, Lynes DM, Yu P, Morrison
    S,Tseng YH*. Re-Establishment of energy balance in a male mouse model with POMC neuron
    deletion of BMPR1A. (2017) Endocrinology 158(12): 4233-4245. *Co-Corresponding Author.
    https://academic.oup.com/endo/article/158/12/4233/4364937
  22. Asalone K. and KL Townsend*. The importance of social sciences in biomedical education and
    doctor-patient interactions. (2017) Accepted with revisions at Journal of Young Investigators.
    *Corresponding Author (not posted online)
  23. AL Waldron, Schroder PA, KL Bourgon, JK Bolduc, JL Miller, AD Pellegrini, AL Dubois, M
    Blaszkiewicz, KL Townsend, S Rieger. Oxidative stress-dependent MMP-13 activity underlies
    glucose neurotoxicity. (2018) J Diabetes Complications, 32(3):249-257.
    https://pubmed.ncbi.nlm.nih.gov/29306589/
  24. An D, Townsend KL, Lee MY, Getchell KM, Tseng YH, Hirshman MF, and Goodyear LJ. Akt2
    Deficient Mice Have Altered Energy Metabolism and Mitochondrial Function in Brown Adipose
    Tissue. Under revised re-submission.
  25. Williams J, Rosner BA, Townsend KL*, Effects of Intermittent Fasting on Body Weight and
    Dyslipidemia: A Meta-Analysis of Studies Conducted Through 2013. Under revised re-submission.
    *Corresponding Author.
  26. Zhang H, Guan M, Huang TL., Townsend KL, An D, Schulz T, Winnay J, Mori M, Goodyear LJ,
    Tsang J, Tseng YH. MicroRNA Determines Brown Fat Differentiation and Thermogenic Function.
    (2015) EMBO reports. 16(10):1378-9.
    https://www.embopress.org/doi/full/10.15252/embr.201540837
  27. Xue R, Lynes MD, Dreyfuss J, Shamsi F, Schulz TJ, Zhang H, Huang TL, Townsend KL, Li Y,
    Takahashi H, Weiner LS, White AP, Lynes MS, Rubin LL, Goodyear LJ, Cypess AM, Tseng Y-H.
    Clonal Analysis and Gene Profiling Identify Genetic Biomarkers of the Thermogenic Potential of
    Human Brown and White Preadipocytes. (2015) Nature Medicine 21(7), 760-8. PMID: 26076036.
    https://pubmed.ncbi.nlm.nih.gov/26076036/
  28. Stanford KI, Middelbeek RJW, Townsend KL, Lee M-Y, Takahashi H, So Kawai, Hitchcox KM,
    Markan KR, Hellbach K, Hirshman MF, Tseng Y-H, Goodyear LJ. A Novel Role for Subcutaneous
    Adipose Tissue in Exercise-Induced Improvements in Glucose Homeostasis. Diabetes. 64(6), 2014.
    PMID 25605808. https://pubmed.ncbi.nlm.nih.gov/25605808/
  29. Schulz TJ, Huang P, Huang TL, McDougall LE, Townsend KL, Cypess AM, Mishina Y, Gussini E,
    Y.-H.Tseng. Impaired Development of Constitutive Brown Adipocytes Due to Loss of BMP Signaling
    Induces Compensatory Browning of White Adipose Tissue. (2013) Nature Mar 21; 495(7441): 379-
    83. PMID: 23485971. https://pubmed.ncbi.nlm.nih.gov/23485971/
  30. Stanford KI, Middelbeek RJW, Townsend KL, An D, Hitchcox KM, Markan KR, Nakano K, Nygaard
    EB, Jung DY, Lee Y, Kim JK, Hirshman MF, Tseng YH, and Goodyear LJ. Brown Adipose Tissue
    Regulates Glucose Homeostasis and Insulin Sensitivity. (2013) J Clin Invest. Jan 2; 123(1):215-23.
    PMID: 23221344. https://pubmed.ncbi.nlm.nih.gov/23221344/
  31. Liew CW, Boucher J, Cheong JK, Vernochet C, Koh HJ, Mallol C, Townsend K, Langin D, Kawamori
    D, Hu J, Tseng Y-H, Hellerstein MK, Farmer SR, Goodyear L, Doria A, Bluher M, Hsu SIH, Kulkarni
    RN. Ablation of TRIP-Br2, a novel regulator of fat lipolysis, thermogenesis and oxidative metabolism,
    prevents diet-induced obesity and insulin resistance. (2013) Nature Medicine Feb;19(2):217-26.
    PMID: 23291629. https://pubmed.ncbi.nlm.nih.gov/23291629/
  32. Townsend KL, An D, Lynes MD, Huang TL, Goodyear LJ, and Tseng YH. Increased Mitochondrial
    Activity in BMP7-treated Brown Adipocytes, Due to Increased CPT1- and CD36-mediated Fatty Acid
    Uptake. (2012) Antioxidants & Redox Signaling. 19(3), 243-57. PMID: 22938691.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691916/31
  33. Townsend KL*, Suzuki R*, Huang TL, Jing E, Schulz T, Lee K, Taniguchi CM, Espinoza DO,
    McDougall LE, He TC, Kokkotou E, and Tseng YH. Bone Morphogenetic Protein 7 (BMP7) Reverses
    Obesity and Regulates Appetite Through a Central mTOR Pathway. (2012). FASEB J, 26(5): 2187-
    96. (* co-first authors) PMCID: PMC3336788.
    https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.11-199067
  34. Schulz TJ, Huang TL, Tran TT, Zhang H, Townsend KL, Shadrach JL, Cerletti M, McDougall L,
    Giorgadze N, Tchkonia T, Schrier D, Falb D, Kirkland JL, Wagers AJ, and Tseng YH. Identification of
    Inducible Brown Adipocyte Progenitors Residing in Skeletal Muscle and White Fat. (2011). Proc Natl
    Acad Sci U.S.A., 108(1): 143-8. PMCID: PMC3017184. https://pubmed.ncbi.nlm.nih.gov/21173238/
  35. Townsend KL, Kunz TH, and Widmaier EP. Changes in body mass, serum leptin, and mRNA levels
    of leptin receptor isoforms during the premigratory period in Myotis lucifugus. (2008) J Comp
    Physiol [B]. 178(2): 217-23. PMID: 17962952. https://pubmed.ncbi.nlm.nih.gov/17962952/
  36. Townsend KL, Lorenzi MM, and Widmaier EP. High-fat diet-induced changes in body mass and
    hypothalamic gene expression in wild-type and leptin-deficient mice. (2008) Endocrine, 33(2):176-
    88. PMID: 18483882. https://pubmed.ncbi.nlm.nih.gov/18483882/
  37. Schulz LC, Townsend KL, Kunz TH, and Widmaier EP. Inhibition of trophoblast invasiveness in vitro
    by immunoneutralization of leptin in the bat, Myotis lucifigus (Chiroptera). (2007) General and Comp
    Endo, 150(1): 59-65. PMID: 16938297. https://pubmed.ncbi.nlm.nih.gov/16938297/
  38. Zhao J, Townsend KL, Schulz LC, Kunz TH, Li C, and Widmaier EP. Leptin receptor expression
    increases in placenta, but not hypothalamus, during gestation in Mus musculus and Myotis lucifigus.
    (2004) Placenta, 25: (8-9). PMID: 15450389. https://pubmed.ncbi.nlm.nih.gov/15450389/

 

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